Table 4.
Urine pharmacokinetic parameters
| Parameter | Normal | Mild | Moderate | Severe |
|---|---|---|---|---|
| Aeur,τ [mg] | ||||
| N | 17 | 8 | 8 | 8 |
| Mean (SD) | 96.261 (35.484) | 122.558 (89.124) | 69.08 (30.021) | 17.344 (15.439) |
| Geometric mean | 89.237 | 105.578 | 63.024 | 11.468 |
| Fe [%] | ||||
| N | 17 | 8 | 8 | 8 |
| Mean (SD) | 21.193 (7.812) | 26.983 (19.622) | 15.209 (6.61) | 7.637 (6.798) |
| Geometric mean | 19.647 | 23.245 | 13.876 | 5.05 |
Aeur,τ Amount of ulifloxacin excreted in urine in the dosing interval, Fe [%] percent fraction of the active dose (ulifloxacin) excreted in the urine, SD standard deviation