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. 2018 Sep 10;8:13508. doi: 10.1038/s41598-018-32008-x

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Hypercapnia alters expression of genes involved in nucleosome assembly. ALI-differentiated NHBE cells were exposed to normocapnia (NC) or hypercapnia (HC) for 24 h prior to analysis. (a) Cluster B genes altered by hypercapnia and their associated GO biologic processes. (b) Hierarchical clustering of the gene expression profiles in normocapnia and hypercapnia. (c) HIST1H2AC, HIST1H2BD and HIST1H2BK mRNA expression assessed by qPCR and hypercapnia was expressed as fold change relative to normocapnia. Results shown are means ± SE; n = 3.