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. 2018 Sep 11;6:26. doi: 10.1038/s41413-018-0027-6

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 2 — Condylar cartilage degeneration in ageing mice at different time points (12 wks, 45 wks and 60 wks). a HE (top) and Safranin O and fast green (bottom) staining analyses of glycosaminoglycan (red), black arrow indicates a crack. Mandibular condylar cartilage cell layers (FC fibrocartilage layer, CC calcified cartilage layer). b FC/CC, c Mankin and d OARSI scores of ageing mice. e Immunohistochemical analyses of Col X, p-Smad2/3 and Osterix (brown) in the mandibular condylar cartilage of ageing mice. f Col X-, p-Smad2/3- and Osterix-positive cells were counted in the cartilage layer. Scale bars = 20 µm. n = 6 per group. *P < 0.05, **P < 0.01 one-way ANOVA followed by Tukey’s test. All data are expressed as the mean ± s.d