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. 2018 Sep 10;9:3667. doi: 10.1038/s41467-018-06027-1

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 7 — Comparison of significantly mutated genes and pathways between moderate/poor and well-differentiated groups. a Group-specific SMGs from the randomisation test based on MutSigCV and OncodriveFM p-values, respectively. Moderate/poor group-specific genes were marked with red circles, while well-differentiated group-specific genes were marked with blue circles. The size of the circle corresponds to its significance compared to that expected by chance. b Mutation OncoPrint of group-specific genes that were expressed across 40 cSCC samples in moderate/poor and well-differentiated groups. Significance level (-log₁₀(p-value)) from the randomisation test was also shown for each gene as bar charts. Genes derived from the OncodriveFM statistics were shown in dark grey, while genes derived from MutSigCV statistics were in light grey. Genes at the top panel appeared to be more moderate/poor group specific, while genes at the bottom panel were more well-differentiated group specific. c Significantly mutated KEGG signalling pathways and d biological processes between moderate/poor and well-differentiated groups. Significant pathways and processes in moderate/poor group only were marked with a dotted square. Pathways and biological processes in the bar charts were sorted with terms significant in both groups at the top, and terms significant in moderate/poor group only at the bottom (indicated with red dashed boxes)