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. 2018 Sep 10;8:13497. doi: 10.1038/s41598-018-31812-9

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Structural alignment of DNA-free GR DBD with previous structures. (A–C) Structural alignments of the 8 monomers found in the crystal structures of free GR-DBD (in grey) overlaid with structures of DNA-bound GR DBD from crystal structures 3G99 (A) and 4HN5 (B) and DNA-free GR DBD from NMR structures 1GDC, 1RGD, and 2GDA (C).