Table 1. Cases of East Asian patients with squamous cell carcinoma harboring ALK/ROS1 fusions.
Author | Year | Race | Gender | Age (years) | Pathology | Smoking status | Stage | Molecular alteration | treatment | Best response | PFS (months) | Reference |
---|---|---|---|---|---|---|---|---|---|---|---|---|
Wang et al. | 2014 | Chinese | Female | 55 | SQCC | Never | IV | ALK fusion | Crizotinib | Partial response | 5.8+ | (118) |
Zhang et al. | 2015 | Chinese | Female | 55 | SQCC | Never | IV | ALK fusion | Crizotinib | Partial response | 6 | (119) |
Wang et al. | 2016 | Chinese | Female | 37 | SQCC | Never | IIIB | ALK fusion | Crizotinib | Partial response | 9+ | (120) |
Mamesaya et al. | 2017 | Japanese-Brazilian | Female | 52 | SQCC | Never | IV | ALK fusion | Alectinib | Partial response | 11+ | (121) |
Li et al. | 2017 | Chinese | Female | 47 | SQCC | Never | IV | ALK-ROS1 fusion | Crizotinib | Partial response | 5 | (122) |
Tamiya et al. | 2015 | Japanese | Male | 78 | SQCC | Ever | Unknown | ALK fusion | Alectinib | Stable disease | 1.5+ | (123) |
PFS, progression-free survival; SQCC, squamous cell carcinoma.