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. 2018 Sep 10;8:13536. doi: 10.1038/s41598-018-31910-8

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Early elevation of soluble markers of platelet activation during sepsis. (a) Levels of plasma soluble CD40L (sCD40L) and eicosanoids at different times in sham and CLP mice. Results are expressed as fold increase and are median (25–75^th percentile) of 4 to 7 independent experiments (*p < 0.05). (b) Kinetics of TxB2, the stable metabolite of TxA2, and (c) 12-HETE production in plasma of sham, CLP-operated mice and CLP-operated mice treated with aspirin. The quantification was performed by a lipidomics LC-MS/MS technique. Results are expressed as fold increase and are median (25–75^th percentile) of 3 to 6 independent experiments (*p < 0.05, **p < 0.01). N.D., not detectable.