Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.
The ERAP1 gene spans 48 kb and comprises 19 exons. The ERAP1 protein consists of four domains: domain I in blue, domain II in orange, domain III in green and domain IV in red. The active site position, including GAMEN and HEXXHX(18)E motifs, is highlighted in domain II. The locations of the autoinflammatory and autoimmune-associated ERAP1 SNPs, including amino acid variation, are shown.
