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. 2018 Aug 3;18(4):3719–3726. doi: 10.3892/mmr.2018.9351

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Copyright: © Liu et al.

This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

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Figure 3. — PDGF-BB promotes osteogenic relative gene expression via the Src/JAK2 signaling pathway. (A) MC3T3-E1 cells were treated with BSA (25 ng/ml), PDGF-BB (25 ng/ml), PDGF-BB (25 ng/ml)+AG1295 (20 µmol/l) and PDGF-BB (25 ng/ml)+SU6656 (2 µmol/l), in osteogenic media for 3 days or (B) for 7 days. Data are presented as the mean ± standard deviation (n=3). *P<0.05, **P<0.01 and ***P<0.001, vs. PD. BSA, bovine serum albumin; PDGF-BB, platelet-derived growth factor-BB; JAK2, Janus kinase 2; NS, not significant; Runx2, Runt-related transcription factor 2; Alp, alkaline phosphatase; Ocn, osteocalcin; Opn, osteopontin; Col1α1, collagen type 1α1.