2.
局部进展期胸腺恶性肿瘤的初始化疗或放化疗
Primary chemotherapy or chemoradiation for locally advanced thymic malignancies
| 研究 | 化疗方案 | 例数 | 肿瘤 | 研究类型 | 后续治疗(%) | ||||||
| 累计周期 | 组织分类 | 分期 | 反应率(%) | 手术 | 完全缓解 | 放疗 | 姑息化疗 | ||||
| CAP,ADOC和PE方案见表 1。CODE方案:顺铂(25 mg/m2/wk),长春新碱(1 mg/m2/wk),阿霉素(40 mg/m2/wk)和依托泊苷(80 mg/m2×3 d/wk);CEE方案:顺铂(75 mg/m2/3 wk),表柔比星(100 mg/m2/3 wk),依托泊苷(120 mg/m2×3 d/3 wk);CAMP方案:CAP+泼尼松龙(1, 000 mg/m2×4 d和500 mg/m2×2 d/3 wk)。 T,胸腺瘤;TC,胸腺癌。 注:本表已获得版权所有者© 2011 by the International Association for the Study of Lung Cancer复制许可。 | |||||||||||
| 化疗 | |||||||||||
| Macchiarini[14] | CEE | 7 | 2 | T/TC | Ⅲ | Phase Ⅱ | 100 | 100 | 57 | 0 | 0 |
| Berruti[16] | ADOC | 6 | 2 | T | Ⅲ-Ⅳa | Phase Ⅱ | 83 | ? | 17 | ? | ? |
| Rea[6] | ADOC | 16 | 6 | T | Ⅲ-Ⅳa | Retrospective | 100 | 100 | 69 | 0 | 0 |
| Venuta[3] | CEE | 15 | 14 | T/TC | Ⅲ | Retrospective | 66 | 100 | ? | ? | ? |
| Bretti[7] | ADOC/PE | 25 | 11 | T/TC | Ⅲ-Ⅳa | Retrospective | 72 | 68 | 44 | ? | ? |
| Kim[15] | CAPP | 22 | 10 | T | Phase Ⅱ | 77 | 100 | 72 | 0 | 0 | |
| Lucchi[4] | CEE | 36 | 27 | T/TC | Ⅲ-Ⅳa | Retrospective | 67 | 69 | 78 | 19 | 3 |
| Jacot[5] | CAP | 5 | 6 | T/TC | Ⅲ-Ⅳa | Retrospective | 75 | 38 | 25 | 50 | 12 |
| Yokoi[8] | CAMP | 14 | 15 | T/TC | Ⅲ,Ⅳa-b | Retrospective | 93 | 64 | 14 | 14 | 21 |
| Kunitoh[17] | CODE | 21 | 8 | T | Ⅲ | PhaseⅡ | 62 | 62 | 43 | 24 | 14 |
| 放化疗 | |||||||||||
| Loehrer[18] | CAP | 23 | 12 | T/TC | Ⅲ-Ⅳa | Phase Ⅱ | 70 | 15 | 0 | 70 | 15 |
| Berruti[19] | ADOC | 16 | 7 | T | Ⅲ-Ⅳa | Phase Ⅱ | 81 | 56 | 56 | 31 | 13 |
| Wright[9] | PE, ADOCCAP, CEE | 10 | 9 | T/TC | Ⅲ-Ⅳa | Retrospective | 40 | 100 | 80 | 0 | 0 |