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. 2018 Sep 10;8:13517. doi: 10.1038/s41598-018-31999-x

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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The biological regulatory network for the genes with inter-sex variability. (A) Represents the network, which was dominantly regulated by NF-κB complex, for genes which were expressed more highly in females on Day 1 and (B) represents the network for genes that were lower expressed in females on Day 1. The color of the squares depicts the physical entities represented. Black node labels denoted the input genes and magenta node labels denote intermediate nodes. The arrow from protein to gene suggested that the protein activates the gene by regulating the DNA; The arrow from protein to RNA suggested that the protein activates the gene by regulating the RNA.