Table 3. Survival analysis in all patients (n=228).
| Variable | n | Survival rate (%) | Univariate, P value | Multivariate, hazard ratio (95% CI) | P value | |
|---|---|---|---|---|---|---|
| 3-year | 5-year | |||||
| Age (yr) | 0.54 | |||||
| <66 | 170 | 30.1 | 15.1 | |||
| ≥66 | 58 | 24.1 | 8.0 | |||
| Sex | 0.36 | |||||
| Male | 134 | 31.7 | 13.5 | |||
| Female | 94 | 24.9 | 14.5 | |||
| Preoperative CA19-9 (U/mL) | 0.043* | 0.35 | ||||
| CA19-9 ≤150 | 102 | 36.3 | 18.2 | 1 | ||
| 150< CA19-9 | 126 | 23.4 | 11.3 | 0.83 (0.56–1.22) | ||
| Proximal additional resection | 0.001* | 0.10 | ||||
| Not performed | 191 | 32.2 | 16.1 | 0.68 (0.43–1.08) | ||
| Performed | 37 | 15.6 | 5.8 | 1 | ||
| LPM | 0.000* | 0.001* | ||||
| LPM ≤10 mm | 102 | 12.8 | 8.5 | 1.96 (1.33–2.89) | ||
| LPM >10 mm | 126 | 40.3 | 18.2 | 1 | ||
| Preoperative biliary drainage | 0.51 | |||||
| Not performed | 54 | 39.2 | 11.0 | |||
| Performed | 174 | 25.1 | 14.3 | |||
| Bismuth type | 0.002* | 0.66 | ||||
| I/II | 63 | 51.5 | 27.3 | 0.89 (0.54–1.47) | ||
| III/IV | 165 | 19.1 | 6.5 | 1 | ||
| Type of hepatectomy | 0.14 | 0.55 | ||||
| Left hepatectomy | 120 | 37.6 | 19.4 | 1 | ||
| Left trisectionectomy | 7 | 20.0 | 14.3 | 1.52 (0.58–4.00) | ||
| Central bisectionectomy | 39 | 19.8 | 0.0 | 1.20 (0.50–2.90) | ||
| Right hepatectomy | 49 | 15.2 | 10.1 | 1.71 (0.68–4.27) | ||
| Right trisectionectomy | 13 | 21.9 | 7.7 | 1.23 (0.37–4.13) | ||
| Combined PV and/or HA | 0.097 | 0.98 | ||||
| Not performed | 158 | 30.7 | 17.6 | 1 | ||
| Performed | 70 | 22.7 | 0.0 | 1.00 (0.66–1.50) | ||
| pTa | <0.001* | <0.001* | ||||
| 1/2a/2b | 58 | 59.0 | 34.5 | 0.18 (0.072–0.44) | ||
| 3/4 | 170 | 13.2 | 0.0 | 1 | ||
| Lymph node metastasis | 0.001* | 0.071 | ||||
| No | 144 | 33.5 | 18.5 | 0.69 (0.46–1.03) | ||
| Yes | 84 | 20.0 | 5.0 | 1 | ||
| pStagea | <0.001* | 0.62 | ||||
| I/II | 42 | 60.8 | 39.9 | 1 | ||
| IIIA/IIIB/IIIC/IVA/IVB | 186 | 18.0 | 3.1 | 1.29 (0.47–3.55) | ||
| Histological grade | 0.045* | 0.25 | ||||
| G1 (well) | 16 | 68.6 | 34.3 | 1 | ||
| G2 (moderately)/G3 (poorly) | 212 | 25.3 | 12.4 | 1.66 (0.70-3.91) | ||
| Microscopic venous invasion | 0.93 | |||||
| Absent | 198 | 26.5 | 13.9 | |||
| Present | 30 | 34.6 | 13.7 | |||
| Microscopic perineural invasion | 0.13 | 0.80 | ||||
| Absent | 108 | 34.4 | 16.4 | 0.95 (0.65–1.40) | ||
| Present | 120 | 18.6 | 9.3 | 1 | ||
| Microscopic liver invasion | 0.041* | 0.23 | ||||
| Absent | 96 | 35.0 | 23.3 | 0.78 (0.52–1.17) | ||
| Present | 132 | 23.6 | 6.3 | 1 | ||
| Proximal ductal margin | <0.001* | |||||
| Negative | 196 | 35.8 | 17.3 | |||
| Positive | 32 | 0.0 | 0.0 | |||
| Distal ductal margin | 0.004* | |||||
| Negative | 209 | 29.5 | 15.0 | |||
| Positive | 19 | 15.7 | 0.0 | |||
| R | <0.001* | <0.001* | ||||
| 0 | 183 | 36.3 | 18.5 | 0.36 (0.23–0.58) | ||
| 1 | 45 | 5.4 | 0.0 | 1 | ||
*, significant difference; a, according to the AJCC TNM classification 8th edition. LPM, length between gross tumor and proximal ductal resection margin; PV, portal vein resection; HA, hepatic artery resection.