Table 1.
Antiproliferative effects of gold(III) compound 1 (expressed as EC50 and Imax values) compared to cisplatin against different human cancer cell lines and non-tumorigenic HEK-293Tcells, after 72 h incubation.
| EC50 (μM)a [Imax(%)] | |||||||
|---|---|---|---|---|---|---|---|
| Compound | A2780 | A2780cisR | HCT116 p53 +/+ | HCT116 p53 –/– | MCF7 | A549 | HEK-293T |
| 1 | 2.4 ± 0.3 [0.044] | 11 ± 0.5 [0.054] | 9.8 ± 0.9 [0.058] | 18.4 ± 1.1 [0.072] | 12 ± 3 [0.03] | 26± 5 [0.041] | 10 ± 3 [0.030] |
| Cisplatin | 2.3 ± 0.5 [0.065] | 30 ± 1 [0.073] | 5.3 ± 0.2 [0.056] | 22.9 ± 2.3 [0.185] | 20 ± 3 [0.124] | 12 ± 1 [0.105] | 8.6 ± 1.3 [0.030] |
a
Data are expressed as mean ± SD (n ≥ 3).