Table 1. Baseline renal hemodynamic parameters and maximal acute vascular responses to ANG II (10 ng), ACh (50 ng), and l-NAME.
| n | RBF (ml.min−1.g−1) | RVR (mmHg/ml.min−1.g−1) | GFR (ml.min−1.g−1) | ANG II (% change in RBF) | ACh (% change in RBF) | l-NAME (% change in RBF) | |
|---|---|---|---|---|---|---|---|
| Non-induced/untreated | 8 | 9.65 ± 0.42 | 13 ± 1 | 0.92 ± 0.07 | 53 ± 6 | 16 ± 2 | −63 ± 3 |
| I3C-induced/untreated | 9 | 5.94 ± 0.891 | 29 ± 31 | 0.75 ± 0.08 | −8 ± 11 | 9 ± 21 | −73 ± 3 |
| I3C-induced/20-HETE antagonist | 8 | 9.98 ± 0.772 | 16 ± 22 | 0.83 ± 0.06 | −45 ± 42 | 18 ± 22 | −64 ± 2 |
| I3C-induced/AT1 receptor blocker | 8 | 9.59 ± 0.752 | 14 ± 12 | 0.94 ± 0.07 | −6 ± 21,3 | 17 ± 32 | −60 ± 32 |
Values are mean ± S.E.M. Abbreviation: I3C-induced, Cyp1a1-Ren-2 transgenic rats fed diet containing 0.3% I3C.
1
P<0.05 compared with non-induced rats.
2
P<0.05 compared with untreated I3C-induced rats.
3
P<0.05 compared with untreated I3C-induced rats/20-HETE antagonist.