Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2018 Aug 16;18(4):3611–3618. doi: 10.3892/mmr.2018.9392

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

Copyright: © Ye et al.

This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

PMC Copyright notice

Figure 3. — Apoptosis is severe and the TGF-β1/Smad2 signaling pathway is significantly activated in Glt25d1^+/− mice. (A) Representative western blots of TGF-β, Glt25d1, cleaved caspase-3, cleaved caspase-9, caspase-9, p-Smad2/3 and Smad2 in the liver. Quantification of individual protein bands of (B) cleaved caspase-3, (C) cleaved caspase-9, (D) TGF-β, (E) p-Smad2 and (F) Glt25d1 were normalized to the corresponding GAPDH levels (n=6–8). *P<0.05, **P<0.01, ***P<0.001; significance determined by Student's t-test or two-way analysis of variance followed by Tukey's test. Glt25d1, collagen β (1-O) galactosyltransferase 1; CCl₄, carbon tetrachloride; WT, wild-type; TGF-β, transforming growth factor-β; Smad, small mothers against decapentaplegic; p-, phosphorylated; NS, not significant.