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. 2018 Sep 10;8:13535. doi: 10.1038/s41598-018-31979-1

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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PGE2 (a) and TGF-ß1 (b) levels in the supernatants of co-cultures of CBFs and T cells. A stepwise increase in TGF-ß1 concentrations with increased numbers of T cells compared to CBF only (Mann-Whitney *p = < 0.05) and other controls, in contrast to PGE2 where these trends were less obvious. (n ≥ 7) in all co-culture ratios and (n = 3) in 8 × 10⁶ T cells/gm of CBF. (c) Positive correlation between TGF-ß1 and T-cell SI in co-cultures of T cells and CBFs (spearman rho r = 0.673, p = <0.05). (d) CBF-driven immunomodulation in the presence of TGF-ß neutralising antibodies or isotype control antibody (co-culture ratio: 1 × 10⁶ T cell/gm CBF) fluorescence histograms for a representative sample (left) and combined data (n = 3, right, paired t test, *p = <0.05).