Table 1.
MSC-specific and immune related molecules from the list of 50 top highly expressed genes in CBFs compared to fibroblasts.
| Gene name | Gene code | Fold-Difference | Reference |
|---|---|---|---|
| Native MSC - specific molecules | |||
| Secreted phosphoprotein 1 (osteopontin), transcript variant 2 | SPP1 | 119.7 | 28, 41 |
| Secreted phosphoprotein 1 (osteopontin), transcript variant 1 | SPP1 | 64.1 | 28, 41 |
| Insulin-like growth factor binding protein 3, transcript variant 1 | IGFBP3 | 38.1 | 28, 29, 41 |
| Bone gamma-carboxyglutamate (gla) protein (osteocalcin) | BGLAP | 36.7 | 28, 41 |
| Lipoprotein lipase (LPL) | LPL | 33.9 | 28, 29, 41 |
| Mesenteric estrogen-dependent adipogenesis | MEDAG | 30.6 | |
| SPARC-like 1 | SPARCL1 | 26.1 | 28 |
| Fatty acid binding protein 4, adipocyte | FABP4 | 25.8 | 28, 41 |
| Insulin-like growth factor binding protein 3, transcript variant 1 | IGFBP3 | 25.4 | 28, 29, 41 |
| Immune related molecules | |||
| S100 calcium binding protein A8 (S100A8) | S100A8 | 62.8 | 28 |
| Interleukin 6 (interferon, beta 2) | IL6 | 61.8 | |
| Prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) | PTGS2 | 40.7 | |
| Defensin, alpha 1 | DEFA1 | 40.3 | |
| Vascular cell adhesion molecule 1 | VCAM1 | 25.8 | 27– 30 |
| Cathelicidin antimicrobial peptide | CAMP | 24.3 | |
| Interferon stimulated exonuclease gene 20 kDa | ISG20 | 24.2 | |
| Defensin, alpha 1 | LOC653600 | 23 | |
| Defensin, alpha 3, neutrophil-specific | DEFA3 | 22.5 | |
| S100 calcium binding protein A12 | S100A12 | 22.4 | |
Immune related molecules were classified based on gene ontology and KEGG pathway analysis using STRING. Native MSC-specific molecules were selected based on published literature.