Table 2.
All immune-related transcripts with at least 2-fold higher expression in CBFs compared to fibroblasts derived from Gene ontology analysis using DAVID.
| Gene name | Gene code | Fold-Change |
|---|---|---|
| Immune response: secreted | ||
| S100 calcium binding protein A8 | S100A8 | 62.8 |
| Interleukin 6 | IL6 | 61.8 |
| Defensin alpha 1 | DEFA1 | 40.3 |
| Complement factor D | CFD | 31.6 |
| Cathelicidin antimicrobial peptide | CAMP | 24.3 |
| Defensin alpha 3 | DEFA3 | 22.5 |
| S100 calcium binding protein A12 | S100A12 | 22.4 |
| Lipocalin 2 | LCN2 | 14 |
| Peptidoglycan recognition protein 1 | PGLYRP1 | 12 |
| Complement factor B | CFB | 6.8 |
| Ficolin 1 | FCN1 | 6.8 |
| CD14 molecule | CD14 | 5.1 |
| Defensin alpha 4 | DEFA4 | 4.9 |
| Haptoglobin | HP | 4.8 |
| High mobility group box 1 | HMGB1 | 4.5 |
| Lysozyme | LYZ | 4.4 |
| Complement factor H | CFH | 4.3 |
| C-C motif chemokine ligand 5 | CCL5 | 4.2 |
| Ribonuclease A family member 4 | RNASE4 | 3.6 |
| Interleukin 1 receptor type 1 | IL1R1 | 3.6 |
| Complement C1q B chain | C1QB | 3.5 |
| Lipopolysaccharide binding protein | LBP | 3.3 |
| Bactericidal/permeability-increasing protein | BPI | 3.2 |
| Interleukin 18 binding protein | IL18BP | 2.9 |
| Ribonuclease A family member 3 | RNASE3 | 2.4 |
| Immune response: others | ||
| Interferon stimulated exonuclease gene 20 kDa | ISG20 | 24.2 |
| Myxovirus resistance 1, interferon-inducible protein p78 | MX1 | 8.7 |
| 2′-5′-oligoadenylate synthetase 2, 69/71 kDa (OAS2) | OAS2 | 8.54 |
| CD55 molecule, decay accelerating factor for complement | CD55 | 6.7 |
| B-cell CLL/lymphoma 6 (zinc finger protein 51) | BCL6 | 4.9 |
| Complement component 1, s subcomponent (C1S) | C1S | 4.9 |
| Hect domain and RLD 5 | HERC5 | 4.7 |
| CD300 molecule-like family member g (CD300LG) | CD300LG | 4.4 |
| V-ets erythroblastosis virus E26 oncogene homolog 1 | ETS1 | 4.2 |
| Bone marrow stromal antigen 2, Tetherin (CD317) | BST2 | 3.3 |
| Mitogen-activated protein kinase kinase kinase 8 | MAP3K8 | 3.1 |
| DEAD (Asp-Glu-Ala-Asp) box polypeptide 3 | DDX3× | 3 |
| Interferon induced transmembrane protein 1 | IFITM1 | 3 |
| Interferon induced with helicase C domain 1 | IFIH1 | 3 |
| Sequestosome 1 | SQSTM1 | 3 |
| FYN oncogene related to SRC, FGR, YES (FYN) | FYN | 2.8 |
| Interferon regulatory factor 7 | IRF7 | 2.8 |
| TANK-binding kinase 1 | TBK1 | 2.7 |
| Adenosine deaminase, RNA-specific, B1 | ADARB1 | 2.7 |
| Interferon-induced protein with tetratricopeptide repeats 2 | IFIT2 | 2.6 |
| Interferon-induced protein with tetratricopeptide repeats 3 | IFIT3 | 2.6 |
| Radical S-adenosyl methionine domain containing 2 | RSAD2 | 2.5 |
| Tripartite motif-containing 56 | TRIM56 | 2.5 |
| Yamaguchi sarcoma viral related oncogene homolog | LYN | 2.4 |
| PR domain containing 1, with ZNF domain | PRDM1 | 2.4 |
Immune related molecules with over 22-fold higher levels compared to fibroblasts are also present in Table 1 (highly expressed).