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The tribranched scaffold utilizes a multi-branched FRET system that remains super-silent in the absence of enzyme. The trimeric structure facilitates vesicular uptake into neutrophils and under the activity of serine proteases the peptide sequence is hydrolysed releasing the methyl red quencher, where upon the fluorescein moieties fluoresce. Q = FRET Quencher, FAM = 5-carboxyfluorescein amide.
