Fig. 4.

Interactions between CVSC and surrounding capsid proteins. The CVSC is shown as cartoon and the remaining structure is rendered as a surface. Capsid proteins contacting the CVSC are highlighted in bright colors and labeled. Model of the UL25-2: Pen–VP5 interface (red inset) highlighting the charge interactions. Interactions between the Ta-binding region of the CVSC and the Ta, P-Hex (blue inset). To show the Ta-binding region clearly, the stalk region is set with 70% transparency. The green and yellow insets show the contacts between the distal region and the Tc, P’-Hex. The color scheme is the same as that of Fig. 1c. The loops in P1 and P6 involved in binding to the CVSC are highlighted in yellow. The N-extensions of two UL25 conformers insert into two cavities of Tc triplex via hydrophobic interactions. Hydrophobic residues from two UL25 conformers and Tc triplex are shown as sticks and presented as gray surface, respectively