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. 2018 Sep 4;9:2014. doi: 10.3389/fimmu.2018.02014

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Copyright © 2018 Pereira, Amoras, da Silva Conde, Demachki, Monteiro, Martins-Feitosa, da Silva, Ishak and Vallinoto.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Heatmap matrix constructed to analyze the liver function profiles according to the histopathological characteristics and −924A>G polymorphism genotypes in CHB-A patients. (A) Regarding inflammatory activity, high hepatic enzyme levels were clustered with low viral loads for patients with the GG genotype with mild to absent inflammatory activity. Another cluster was formed among patients with low hepatic enzyme levels and high viral loads in AA genotype individuals with low tissue inflammation. (B) Regarding liver fibrosis, elevated liver enzyme levels were clustered with intermediate viral loads for GG genotype patients with mild to absent fibrosis.