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. 2018 Sep 10;8:13489. doi: 10.1038/s41598-018-31657-2

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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p300G422S-KI at the age of 6 months shows reduced hippocampal contextual fear memory. (a) Both 3 and 6 months homozygous p300G422S-KI and their WT littermates, were pre-exposed to the conditioning context at day one, and received an immediate shock (1.0 mA, 2 seconds) within the same context at day two. Percentage of time spent freezing within the first two minutes when the mice were re-placed in the conditioning context at day three without shock. *p < 0.05 (b) Open field test was performed in an open box for 10 minutes. The cumulative time spent within the center and all 4 corners of the box was analyzed. Insets show representative traces of WT and p300G422S -KI mouse during the course of the open field test. (c) Analysis of the total distance travelled during the open field test for WT and p300G422S -KI mice at the age of 3 and 6 months. (d) Analysis of the mean velocity during the open field test at the age of 3 and 6 months. n = 8–13 animals for each group.