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Proposed cytokine signaling pathway triggered by internalized free IgG antibody. The 3D8 IgG-N434D mutant, which is not recognized by TRIM21, induces human monocytes to produce more IL-8 and TNF-α than cells exposed to wt 3D8 IgG. An as-yet-unknown cytosolic Fc sensor may be responsible for cytokine signaling triggered by entry of free IgG to the cytosol.
