Table 2.

Regulation of ASCT2.

Tissue	Regulatory factor	Effect	References
Hepatoma cells	Glutamine through FXR/RXR	Upregulation	Bungard and McGivan, 2004, 2005
	mTOR inhibition by rapamycin	Downregulation	Fuchs et al., 2007
	c-Myc	Upregulation	Liu P. et al., 2017
Breast cancer HR positive	c-Myc, EphA2	Upregulation	Gao et al., 2009; Chen et al., 2015
	Ubiquitine ligase	Degradation	Jeon et al., 2015; Moses and Neckers, 2015
	IL4 and IL4R	Upregulation	Venmar et al., 2015
	PPAR delta	Upregulation	Zhang et al., 2017
Colon cancer	Repression of miRNA-137	Upregulation	Dong J. et al., 2017
	MAPK-PI3K	Increased stability	Avissar et al., 2008
	PPAR delta	Upregulation	Zhang et al., 2017
Cervical cancer	Lactate	Upregulation	Pérez-Escuredo et al., 2016
	PPAR delta	Upregulation	Zhang et al., 2017
Leukemia cells	Inhibition of glucose metabolism	Downregulation	Polet et al., 2016
MEF	Down-regulation of pRb	Upregulation	Reynolds et al., 2014
Oocytes expressing hASCT2	SGK1, 3 and PKB	Increased abundance in plasma membrane	Palmada et al., 2005
Porcine enterocytes	mTOR and AMP	Upregulation	Yi et al., 2015
Rat Intestine	Leptin	Downregulation	Ducroc et al., 2010
Rat enterocytes	Aldosterone	Upregulation	Amaral et al., 2008
Mouse mammary gland	GPCR	Upregulation	Liu J. et al., 2017
Infection by Salmonella enterica	mTOR	Upregulation	Tattoli et al., 2012

In plain text, studies conducted in cancer cells, in italics studies conducted in normal cells.