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. 2018 Sep 4;9:1994. doi: 10.3389/fimmu.2018.01994

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Copyright © 2018 Li, Huang, Jiang, Chen, Zhang, Wei, Chen, Lian, Bian, Miao, Peng, Fang, Wang, Tang, Gershwin and Ma.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Phenotype and function alterations of circulating MAIT cells in NAFLD patients. (A) CD69⁺ and PD-1⁺ expression on MAIT cells in HC and NAFLD patients. (B) Higher frequency of CXCR6⁺ MAIT cells in NAFLD patients compared to HC, and high frequency of CCR5⁺ MAIT cells in both 2 groups without statistical difference. (C) Representative examples of intracellular cytokines staining (Left panel) and the frequency of MAIT cells from HC and NAFLD patients that produced IFN-γ, TNF-α or IL-4 after stimulation with PMA-ionomycin (Right panel). (HC, n = 20; NAFLD patients, n = 25). (D) IL-4 concentrations in PBMCs supernatant from HC and NAFLD patients with PMA-ionomycin stimulation. (n = 15). Data were analyzed with Mann–Whitney U-test.*P < 0.05, **P < 0.01, ns: no statistical significance.