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. 2018 Sep 4;9:1994. doi: 10.3389/fimmu.2018.01994

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Copyright © 2018 Li, Huang, Jiang, Chen, Zhang, Wei, Chen, Lian, Bian, Miao, Peng, Fang, Wang, Tang, Gershwin and Ma.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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More severe hepatic steatosis and inflammation in MR1^−/− -MCD mice compared with WT-MCD mice. WT serum ALT levels (A) and liver-to-body weight ratio (B) in WT and MR1^−/− mice on ND and MCD. (C) The gross picture, HE and ORO staining of livers from WT and MR1^−/− mice on ND and MCD (original magnification, × 100) (n = 10). TG level (D) and NAS (E) of livers in mice in WT and MR1^−/− mice upon ND and MCD (n = 10). Data were analyzed using ANOVA with Bonferroni test comparison. *P < 0.05, **P < 0.01, ***P < 0.001. ALT, alanine aminotransferase; HE, hematoxylin and eosin; ORO, oil red O; TG, triglyceride; NAS, NAFLD activity score.