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Schematic diagram illustrating the role of MAIT cells in homeostasis and NAFLD. In the development of NAFLD, FFA induces MR1 expression increase in kupffer cells (KC). Circulating MAIT cells are recruited to the liver and then activated in MR1-dependent manner, secreting more Th2 type cytokines with less Th1 type cytokine. Consequently, activated MAIT cells induce M2 macrophage polarization, providing protection against inflammation in NASH.
