Table I.
List of seed pathways between AS and control.
| Pathways | False discovery rate |
|---|---|
| hsa05200: Pathways in cancer | 1.48×10−23 |
| hsa05161: Hepatitis B | 1.26×10−14 |
| hsa05215: Prostate cancer | 1.93×10−14 |
| hsa05212: Pancreatic cancer | 5.37×10−13 |
| hsa04151: PI3K-Akt signaling pathway | 3.25×10−12 |
| hsa05220: Chronic myeloid leukemia | 3.94×10−11 |
| hsa05214: Glioma | 1.17×10−10 |
| hsa05211: Renal cell carcinoma | 1.43×10−10 |
| hsa05218: Melanoma | 3.77×10−10 |
| hsa05219: Bladder cancer | 1.01×10−9 |
| hsa05222: Small cell lung cancer | 4.47×10−9 |
| hsa04510: Focal adhesion | 3.68×10−8 |
| hsa04066: HIF-1 signaling pathway | 4.21×10−8 |
| hsa04520: Adherens junction | 7.60×10−8 |
| hsa05203: Viral carcinogenesis | 1.96×10−7 |
| hsa04110: Cell cycle | 3.88×10−7 |
| hsa04540: Gap junction | 6.07×10−7 |
| hsa05223: Non-small cell lung cancer | 6.97×10−7 |
| hsa04012: ErbB signaling pathway | 3.96×10−6 |
| hsa05169: Epstein-Barr virus infection | 4.10×10−6 |
| hsa04010: MAPK signaling pathway | 4.37×10−6 |
| hsa04912: GnRH signaling pathway | 6.60×10−6 |
| hsa04320: Dorso-ventral axis formation | 7.68×10−6 |
| hsa04730: Long-term depression | 1.26×10−5 |
| hsa05131: Shigellosis | 2.05×10−5 |
| hsa05166: HTLV-I infection | 2.12×10−5 |
| hsa04115: p53 signaling pathway | 3.21×10−5 |
| hsa05120: Epithelial cell signaling in Helicobacter pylori infection | 3.21×10−5 |
| hsa05213: Endometrial cancer | 4.22×10−5 |
| hsa04910: Insulin signaling pathway | 5.07×10−5 |
| hsa05145: Toxoplasmosis | 6.38×10−5 |
| hsa04722: Neurotrophin signaling pathway | 6.86×10−5 |
| hsa04916: Melanogenesis | 9.53×10−5 |
| hsa04350: TGF-β signaling pathway | 1.05×10−4 |
| hsa05142: Chagas disease (American trypanosomiasis) | 1.20×10−4 |
| hsa05210: Colorectal cancer | 1.33×10−4 |
| hsa04810: Regulation of actin cytoskeleton | 1.58×10−4 |
| hsa05216: Thyroid cancer | 1.67×10−4 |
| hsa04062: Chemokine signaling pathway | 1.81×10−4 |
| hsa04725: Cholinergic synapse | 2.26×10−4 |
| hsa04726: Serotonergic synapse | 2.42×10−4 |
| hsa04664: Fc epsilon RI signaling pathway | 2.87×10−4 |
| hsa04360: Axon guidance | 5.40×10−4 |
| hsa05221: Acute myeloid leukemia | 5.98×10−4 |
| hsa04660: T cell receptor signaling pathway | .6.42×10−4 |
| hsa04728: Dopaminergic synapse | 6.77×10−4 |
| hsa05160: Hepatitis C | 7.56×10−4 |
| hsa04150: mTOR signaling pathway | 7.88×10−4 |
| hsa05132: Salmonella infection | 1.01×10−3 |
| hsa04114: Oocyte meiosis | 1.11×10−3 |
| hsa04064: NF-κB signaling pathway | 1.41×10−3 |
| hsa04144: Endocytosis | 1.88×10−3 |
| hsa04662: B cell receptor signaling pathway | 2.05×10−3 |
| hsa04380: Osteoclast differentiation | 2.85×10−3 |
| hsa05100: Bacterial invasion of epithelial cells | 2.89×10−3 |
| hsa05016: Huntington's disease | 2.95×10−3 |
| hsa04620: Toll-like receptor signaling pathway | 3.37×10−3 |
| hsa05010: Alzheimer's disease | 3.82×10−3 |
| hsa04621: NOD-like receptor signaling pathway | 3.89×10−3 |
| hsa04210: Apoptosis | 5.01×10−3 |
| hsa04370: VEGF signaling pathway | 5.21×10−3 |
| hsa04512: ECM-receptor interaction | 5.30×10−3 |
| hsa05034: Alcoholism | 5.99×10−3 |
| hsa04666: Fc γ R-mediated phagocytosis | 6.59×10−3 |
| hsa04720: Long-term potentiation | 7.75×10−3 |
| hsa04330: Notch signaling pathway | 1.12×10−2 |
| hsa04961: Endocrine and other factor-regulated calcium reabsorption | 1.16×10−2 |
| hsa05162: Measles | 1.18×10−2 |
| hsa04310: Wnt signaling pathway | 1.48×10−2 |
| hsa05164: Influenza A | 1.61×10−2 |
| hsa05152: Tuberculosis | 1.71×10−2 |
| hsa05130: Pathogenic Escherichia coli infection | 1.84×10−2 |
| hsa05168: Herpes simplex infection | 2.10×10−2 |
| hsa04914: Progesterone-mediated oocyte maturation | 2.32×10−2 |
| hsa05020: Prion diseases | 2.83×10−2 |
| hsa04713: Circadian entrainment | 3.34×10−2 |
| hsa04650: Natural killer cell mediated cytotoxicity | 4.11×10−2 |
| hsa04723: Retrograde endocannabinoid signaling | 4.16×10−2 |
| hsa04530: Tight junction | 4.24×10−2 |
| hsa05202: Transcriptional misregulation in cancer | 4.77×10−2 |
| hsa04971: Gastric acid secretion | 4.96×10−2 |
| hsa05133: Pertussis | 4.97×10−2 |
PIK3, phosphatidylinositol 3-kinase; Akt, RAC-α serine/threonine-protein kinase; HIF1, hypoxia-inducible factor 1; ErbB, receptor tyrosine-protein kinase; MAPK, mitogen-activated protein kinase; GnRH, gonadotropin-releasing hormone; HTLV-1, human T-cell lymphotrophic virus type 1; p53, cellular tumor antigen p53; mTOR, serine/threonine-protein kinase mTOR; NF, nuclear factor; NOD, nucleotide oligomerization domain; VEGF, vascular endothelial growth factor; ECM, extracellular matrix.