Figure 3.

Effects of Sirt3 on cisplatin-induced neutrophil infiltration. (A) Representative Immunohistochemistry staining for Gr-1-positive neutrophils in the kidneys of WT and Sirt3KO mice treated with vehicle or cisplatin. Scale bar, 50 µm. (B) Bar graph of the number of Gr-1-positive cells in WT and Sirt3KO mice kidneys following treatment with vehicle or cisplatin. A total of 10 randomly selected, nonoverlapping fields were quantified (n=10 in each group; magnification, ×400). Data were expressed as the mean ± standard deviation. ***P<0.001 vs. Veh; ^###P<0.001 vs. WT cisplatin. Gr-1, lymphocyte antigen 6 complex, locus G; Veh, vehicle; WT, wild type; Sirt3, Sirtuin 3; KO, knockout.