Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.
The proposed “two-hit” model in autophagy-mediated NETosis. Initially, various stimuli derived from the inflammatory microenvironment stimulate the production of disease-related proteins in naïve neutrophils (first-hit). Subsequently, triggering of autophagy (second-hit) leads to NET formation and the extracellular release of proteins via NET scaffold, contributing to antimicrobial capacity or inflammatory potential of the cell.
