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. 2018 Sep 4;12:199. doi: 10.3389/fnbeh.2018.00199

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Copyright © 2018 Meneely, Dinkins, Kassai, Lyu, Liu, Lin, Brewer, Li and Clemens.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Thermal pain withdrawal latencies of WT, Meis1KO, and D3KO before and after D3 receptor agonist (PPX) treatment. (A1) Normalized representation of data from WT_meis1 animals. PPX significantly increased withdrawal latencies. (A2) Normalized representation of data from the Meis1KO animals. As in WT_meis1, PPX significantly increased withdrawal latencies. (B1) Normalized representation of data from WT_D3KO animals. PPX significantly increased withdrawal latencies. (B2) Normalized representation of data from D3KO animals. Unlike in both WT lines and Meis1KO, the D3 receptoer agonist PPX had no effect on withdrawal latencies in D3KO.