Table 3.
Stimulatory effects of retinoid compounds in inflammatory disorders.
| Target mechanisms/tissues | Induced effects | References |
|---|---|---|
| T - cell immunity | Maintenance of T-cells and attenuation of inflammation | (70) |
| B-cell proliferation | Regulation and differentiation by retinoic acid | (71) |
| Cytokine induction | Stimulatory overproduction of interleukins - 1 and - 3 | (72) |
| T-cell immunity | Cellular induction via T-killer cell induction | (73) |
| RA-receptors | Dualistic influences on Th1 and Th2 development | (74) |
| Keratin genes | Maturation of filament proteins forming keratin | (75) |
| Red blood cells | Combined effects of TH and RA on erythropoiesis | (76) |
| RA effects on leukocytes | Antagonistic effects of Il-10, Il-12 and TNFα | (77) |
| Activated B – cells | Promotion of CD4(+) T cell differentiation | (78) |
| CD8 T-cell activation | Modulation of T-cells differentiation by RAs | (79) |
| Epidermal growth factor | Control of EGF binding and mitogenic activities | (80) |
| Skin fibroblasts | Proliferation of extracellular matrix of dermal fibroblasts | (81) |