Table II.

GO analysis of differentially expressed genes associated with gastric cancer.

A, Upregulated BP
GO term	Function	Count	P-value
GO:0030198	Extracellular matrix organization	60	8.71×10−33
GO:0007155	Cell adhesion	84	2.77×10−28
GO:0006954	Inflammatory response	71	4.15×10−23
GO:0030574	Collagen catabolic process	27	7.35×10−19
GO:0050900	Leukocyte migration	44	4.32×10−16
B, Upregulated MF
GO term	Function	Count	P-value
GO:0008201	Heparin binding	40	5.50×10−19
GO:0005201	Extracellular matrix structural constituent	27	1.27×10−18
GO:0005178	Integrin binding	30	6.20×10−16
GO:0005515	Protein binding	466	3.03×10-10
GO:0050840	Extracellular matrix binding	12	4.26×10−9
C, Upregulated CC
GO term	Function	Count	P-value
GO:0031012	Extracellular matrix	88	2.87×10−48
GO:0005576	Extracellular region	186	1.45×10−36
GO:0005578	Proteinaceous extracellular matrix	71	2.96×10−35
GO:0005615	Extracellular space	161	5.22×10−33
GO:0070062	Extracellular exosome	225	1.94×10−21
D, Downregulated BP
GO term	Function	Count	P-value
GO:0006805	Xenobiotic metabolic process	24	5.27×10−13
GO:0055114	Oxidation-reduction process	67	3.82×10−11
GO:0008202	Steroid metabolic process	16	4.19×10−10
GO:0030855	Epithelial cell differentiation	16	6.14×10−7
GO:0007586	Digestion	15	9.10×10−7
E, Downregulated MF
GO term	Function	Count	P-value
GO:0016491	Oxidoreductase activity	26	7.08×10−6
GO:0070403	NAD+ binding	6	2.06×10−4
GO:0004033	Aldo-keto reductase (NADP) activity	6	4.44×10−4
GO:0004062	Aryl sulfotransferase activity	5	1.7×10−3
GO:0004022	Alcohol dehydrogenase (NAD) activity	4	3.1×10−3
F, Downregulated CC
GO term	Function	Count	P-value
GO:0070062	Extracellular exosome	198	2.96×10−9
GO:0005782	Peroxisomal matrix	12	7.33×10−6
GO:0016324	Apical plasma membrane	32	2.21×10−5
GO:0005789	Endoplasmic reticulum membrane	69	2.47×10−5
GO:0016021	Integral component of membrane	295	9.53×10−5

GO, gene ontology; BP, biological process; CC, cellular component; MF, molecular function.