Table 5.

Effects of PrEP on number of sexual partners.

Study name	Outcome	Description
RCTS: PrEP vs. NO PrEP
CDC safety study	Mean number of male sex partners in past 3 months	Decreased significantly from 7.25 at baseline to 6.02 during months 3–9 and 5.71 during months 12–24 (P < 0.001). Declines were similar between the immediate vs. delayed arms during months 3–9 (P value for interaction = 0.67) Mean number did not differ in months 12–24 vs. months 3–9 with initiation of study drug in delayed arm (p = 0.22) or drug continuation in immediate arm (IRR = 0.96, P = 0.56). Mean number of positive or unknown HIV-status partners declined from 4.17 at baseline to 3.51 during months 3–9 (P = 0.04) and 3.37 during months 12–24 (P = 0.01).
iPrEx study	Mean number of receptive anal partners	Baseline: FTC-TDF: 12.21 (SE = 0.81); Placebo: 11.21 (SE = 0.81) Follow-up (132 weeks): FTC-TDF: 3.47 (SE = 0.81); Placebo: 5.71 (SE = 1.59) Wald test of the treatment by visit interaction: p = 0.97
Ipergay	Number of sexual partners in the past 2 months	There was a slight but significant decrease in the number of sexual partners within the past 2 months in the placebo group as compared with the TDF-FTC group
OBSERVATIONAL STUDIES: CHANGE DURING PrEP USE OR COMPARISON BETWEEN PRE/POST PrEP
iPrEx OLE	Number of sexual partners	Numbers of sexual partners were much the same in the each groups (p = 0.64)
Ipergay	Number of sexual partners in the past 2 months	There was a slight but significant decrease in the number of sexual partners within the past 2 months in the placebo group as compared with the TDF-FTC grou
Ipergay OLE	Number of sexual partners during the 2 months before visit Total number of sexual intercourses in the 4 weeks before visits	No significant change during the 2 months before visits (p = 0.42)and the total number of sexual intercourses in the 4 weeks before visits (p = 0.12)
KPSF	Number of sexual partners every 1–3 months after PrEP initiation	Unchange:74% of PrEP users, decrease:15% of PrEP users, and increase:11% of PrEP users after 6 months
NCT01632995	Number of anal sex partners in the past three months	Declined from 10.9 at baseline to 9.3 at week 48 (p = 0.04)
PROUD-pilot phase	Number of anal sex partners in last 90 day	At baseline: immediate arm: 10.5 (5–20); delayed arm: 10 (4–20) and at month 12: immediate arm: 10 (3–24); delayed arm: 8 (3–15)