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. 2018 Sep 4;11:309. doi: 10.3389/fnmol.2018.00309

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Copyright © 2018 Kerr, García-Contreras, Abbassi, Mejias, Desousa, Ricordi, Dietrich, Keane and de Rivero Vaccari.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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ASC is elevated in serum-derived EV of stroke patients. Protein levels in pg/ml of ASC (A), IL-1β (B) and IL-18 (C) in serum-derived EV from patients with stroke and healthy donors. p-value of significance is shown above each box plot. Box and whiskers are shown for the 5th and 95th percentile. N.S., Not Significant. ASC: N = 16 control and 16 stroke; IL-1β: N = 10 control and 9 stroke; and IL-18: N = 16 control and 13 stroke. (D) ROC curves for ASC (blue), IL-1β (black) and IL-18 (green). ASC: N = 16 control and 16 stroke; IL-1β: N = 10 control and 9 stroke; and IL-18: N = 16 control and 13 stroke.