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. 2018 Sep 4;9:1000. doi: 10.3389/fphar.2018.01000

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Copyright © 2018 Gonçalves, Benoit, Partiseti and Servent.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Cellular elements involved in pain transmission from the peripheral to the central nervous system (CNS). (Box 1) The pain (thermal, high pressure, mechanical, chemical) information is first detected by the receptors located at the level of free nerve endings of primary sensory neuron (PSN) fibers. (Box 2) Then, it is conveyed by the dendrites of these neurons, components of dorsal root ganglia (DRG), to the dorsal horn of spinal cord where it is transmitted to the dendrites of secondary sensory neurons (SSNs). (Box 3) Finally, it is brought to the hypothalamus via the tertiary sensory neurons (TSNs) whose cell bodies constitute, in part, the brain cortex.