FIGURE 4.
Relative proportion of NaV channel α-subunits detected in mammalian dorsal root ganglia (DRG) neurons by RT-PCR. DRG neurons are from some representative mammals of different orders reported in the literature: primates, artyodactyla and rodents. The first order, including human and monkey, is closely related to the pig, belonging to the second order. The rodents, more distant from the human, represent the model often used for pain studies. The adult post-mortem human DRG neurons were obtained from healthy donors. All the data are from DRG neurons of adult mammals except those from 7 day-old rats. ND, non-determined. Adapted from Raymond et al. (2004), Berta et al. (2008), Ho and O’Leary (2011), Muroi and Undem (2014), and Chang et al. (2018).