Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2018 Sep 4;9:1000. doi: 10.3389/fphar.2018.01000

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

Copyright © 2018 Gonçalves, Benoit, Partiseti and Servent.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

PMC Copyright notice

Sequence alignment obtained by Multalin (version 5.4.1) of different potential analgesic toxins sorted by Na_V spider toxins families, using their UniProtKB identifiers. The consensus sequence is shown above each alignment, with the disulfide bond connectivity. In dark blue, highly conserved amino acid residues (100%), and in light blue, poorly conserved amino acid residues (>50%). The Greek letter(s) before the toxin name is associated to its type of action: μ for Na_V channel inhibition, β for shift in the voltage-dependence of Na_V channel activation, ω for Ca_V channel inhibition, and κ for K_V channel inhibition. ProTx, protoxin; HnTx, hainantoxin; CcoTx, ceratotoxin; HwTx, huwentoxin; JzTx, jingzhaotoxin; aa, amino acid residues; NaSpTx, spider Na_V channel toxin.