Table 1.

Representative Chalcones from Natural Sources^27–66

Entry	Name	Structure	Activity	Natural Source
Classical chalcones
1	isoliquiritigenin27-29		Anti-cancer Cancer chemopreventive Anti-oxidant Anti-inflammation	Nepalese propolis
2	butein30,31		Anti-cancer Anti-inflammation	Rhus verniciflua
3	cardamonin32		Schistosoma mansoni ATP diphosphohydrolase	Piper aduncum L.
4	sappanchalcone33,34		Anti-inflammation	Sappan Lignum
5	3-deoxysappanchalcone33
6	isobavachalcone35,36		Anti-oxidant α-Glucosidase inhibitory activity Cancer chemopreventive Anti-cancer Anti-bacterial Anti-fungal	Psoralea corylifolia (Leguminosae) Kadsura ananosma
7	bavachalcone37		Anti-bacterial	Psoralea corylifolia
8	ajejuchalcone A38		NDb	Apis mellifera
9	ajejuchalcone B38
10	ajejuchalcone C38
11	ajejuchalcone D38
12	ajejuchalcone E38
13	ajejuchalcone F38
14	a(±)-jejuchalcone G38
15	morachalcone A39		Cytotoxicity	Maclura pomifera
16	broussochalcone A40		Protein kinase C inhibitor	Broussonetia papyrifera
17	xanthohumol41-43		Anti-HIV-1 Anti-bacterial Anti-cancer	Hops Humulus lupulus/Angelica keiskei/Koidzumi
18	xanthoangelol44,45		Anti-cancer	Angelica keiskei/Psorala corylifolia
19	gemichalcone C46		ND	Hypericum geminiflorum
20	isogemichalcones B47		Cytotoxicity	Hypericum Geminiflorum
21	isogemichalcones C48		Cytotoxicity	Broussonetia papyrifera
22	spinochalcone A49		Cytotoxicity	Aeschynomene fascicularis
23	spinochalcone C49		ND	Aeschynomene fascicularis
24	candidachalcone50		Estrogenic activity	Tephrosia Candida
25	4’-O-methylbavachalcone35		α-Glucosidase inhibitory activity	Psoralea corylifolia
26	isobavachromene35		α- Glucosidase inhibitory activity	Psoralea corylifolia
27	licochalcone A51,52		Anti-inflammation Anti-cancer	Glycyrrhiza inflata
28	oxyphyllumchalcone A26		Cytotoxicity	Desmodium oxyphyllum
29	oxyphyllumchalcone B26
30	oxyphyllumchalcone c26
31	pinostrobin chalcone53		Cytotoxicity	Alpinia mutica
32	amillepachine54		Anticancer	Millettia pachycarpa
33	a4,2’,4’-trihydroxy-3′-[(2E,5E)-7-methoxy-3,7-dimethyl-2,5-octadienyl]chalcone55		Heat shock protein promoter activity	Angelica keiskei Koidzumi (aerial parts)
34	a(±)-4,2′,4′-trihydroxy-3′-[(2E)-6-hydroxy-7-methoxy-3,7-dimethyl-2-octenyl]chalcone55
35	a4,2′, 4′ -trihydroxy-3′ -[(2E)-3-methyl-5-(1,3-dioxolan-2-yl)-2-pentenyl]chalcone55
36	a2′,3′-furano-4-hydroxy-4′-methoxychalcone55
37	a(±)-4-hydroxy-2±,3± -(2,3-dihydro-2-methoxyfurano)-4± -methoxychalcone55
38	a(-)-rubrichalcolactone56		ND	Cryptocarya rubra
39	rhuschalcone II23		Cytotoxicity	Rhus pyroides
40	rhuschalcone III23
41	rhuschalcone IV23
42	rhuschalcone V23
43	verbenachalcone57		Enhancement of nerve growth factor-mediated neurite outgrowth	Verbena littoralis
44	afleminchalcone A24		Tyrosinase inhibitor	Flemingia philippinensis
45	afleminchalcone B24
46	aflemiphilippinone B58		Anti-proliferative activity Apoptosis-inducing property	Flemingia philippinensis
47	aflemiphilippinone C58		Anti-proliferative activity Apoptosis-inducing property	Flemingia philippinensis
48	elastichalcone A59		ND	Artocarpus elasticus
49	elastichalcone B59		Free radical scavenging inhibitory activity	Artocarpus elasticus
50	elatadihydrochalcone60		Anti-plasmodial	Tephrosia elata
51	chinendihydrochalcone61		Anti-fungal and cytotoxicity	Desmos chinensis (stem barks)
Chalcone mimics/Fused chalcones
52	a4-cinnamoyl-4-hydroxy-3-methoxycyclohex-2-enone62		Nitric oxide production inhibitory activity	Nepalese propolis
53	schefflerichalcone63		Non-toxic	Uvaria scheffleri
54	atunicatachalcone64		ND	Tephrosia tunicate (roots)
55	akamalachalcone E65		Anti-fungal	Mallotus philippinensis
56	aoxyfadichalcone A26		ND	Oxytropis falcata
57	aoxyfadichalcone B26
58	aoxyfadichalcone C26
59	anardoaristolone A66		Protective effects on H2O2-induced myocardial injury	Nardostachys chinensis

^aFirst report of the isolation of chalcone from a natural source.

^bThe biological activities have not been determined in the references (ND = not determined).