Table 2.

Mass Spectrometry Data for β-Lactamases Incubated with DBOs for 5 min and 24 h

		5 min		24 h
sample	inhibitor	molecular weight (MW)	ΔMW(ΔDBO)	MW	ΔMW (ΔDBO)
KPC-2	none	28,723	+0	28,724	+0
KPC-2	3	28,971	+247	28,971	+247
KPC-2	2	29,115	+392	29,115	+392
KPC-2	1	29,101	+378	29,101	+378
KPC-2	avibactam	28,989	+266	28,989	+265
				28,892	+168 (−97)
KPC-2	relebactam	29,071	+349	29,072	+350
ADC-7	none	40,639	+0	40,640	+0
ADC-7	3	40,639 (minor)	+0	40,640	+0
		40,886	+248	40,887	+247
		40,806 (minor)	+166 (−80)	40,806 (minor)	+166 (−80)
ADC-7	2	40,639 (minor)	+0	40,640	+0
		41,030	+391	41,031 (minor)	+247
ADC-7	1	40,639	+0	40,640	+0
		41,016	+377	41,018 (minor)	+377
ADC-7	avibactam	40,640 (minor)	+0	40,641	+0
		40,904	+264	40,905	+264
		40,824 (minor)	+185 (−80)	40,824	+185 (−80)
ADC-7	relebactam	40,639 (minor)	+0	40,989	+348
		40,987	+349
PDC-3	none	40,654	+0	40,655	+0
		40,785	+0	40,786	+0
PDC-3	3	41,033	+246	41,033	+246
		40,902	+246	40,903	+246
		40,951 (minor)	+166 (−80)	40,951 (minor)	+166 (−80)
		40,820 (minor)	+166 (−80)	40,822 (minor)	+166 (−80)
PDC-3	2	41,177	+394	41,178	+394
		41,046	+394	41,046	+394
PDC-3	1	41,163	+383	41,163	+383
		41,032	+383	41,032	+383
PDC-3	avibactam	41,051	+265	41,051	+265
		40,920	+265	40,920	+265
		40,970 (minor)	+185 (−80)	40,970 (minor)	+185 (−80)
		40,840 (minor)	+185 (−80)	40,840 (minor)	+185 (−80)
PDC-3	relebactam	41,134	+353	41,134	+353
		41,003	+353	41,004	+353
OXA-23	none	27,494	+0	27,494	+0
OXA-23	3	27,494 (minor)	+0	27,494 (minor)	+0
		27,740	+246	27,741	+247
		27,660 (minor)	+166 (−80)	27,660 (minor)	+167 (−80)
OXA-24/40	none	28,664	+0	28,664	+0
OXA-24/40	3	28,664 (minor)	+0	28,665 (minor)	+0
		28,911	+247	28,912	+247
		288,32 (minor)	+166 (−80)	28,832 (minor)	+166 (−80)
OXA-48	none	28,283	+0	28,290	+0
OXA-48	3	28,283 (minor)	+0	28,286 (minor)	+0
		28,530	+247	28,533	+247
		28,449 (minor)	+166 (−80)	28,451 (minor)	+166 (−80)
OXA-48	avibactam	28,549	+266	28,551	+265
		28,468 (minor)	+185 (−80)