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. 2018 Sep 11;6(17):e13829. doi: 10.14814/phy2.13829

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© 2018 The Authors. Physiological Reports published by Wiley Periodicals, Inc. on behalf of The Physiological Society and the American Physiological Society.

This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.

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Change is serum carboxyhemoglobin (%) over test 1 and 2 (T1 and T2) of each procedure. Results are presented as median and range. Safety of duplicating the oCOR method is dependent on ensuring that the clearance procedure removes enough COHb after T1 to avoid excess COHb (>10%, red dotted line) during T2. Seven‐minute values are calculated and not measured values but are included as they are used to calculate COHb. COHb: carboxyhemoglobin; oCOR, optimized carbon monoxide rebreathing technique; PROC _A/B/C, Procedure A/B/C, T1: test 1 or first measurement of the day, T2: test 2 or second measurement of the day.