Table 3.

Clinical factors potentially influencing colostomy-free survival

		Univariable			Multivariable			SIB vs SeqB, Propensity score adjusted
Endpoint	Parameter	HR	95%CI	p	HR	95%CI	p	HR	95%CI	p
CSF	SIB	0.90	0.53,1.54	0.703	1.18	0.67,2.09	0.560	1.15	0.65,2.04	0.621
	SIB on the first 24 months	0.72	0.38,1.34	0.297	0.95	0.49,1.84	0.877	0.95	0.48,1.85	0.871
	Sex (M vs F)	1.64	0.93,2.90	0.087	1.60	0.90,2.84	0.109
	Age	1.02	1.00,1.04	0.119	1.02	1.00,1.04	0.124
	Stage III vs I-II	1.78	1.03,3.05	0.037	1.83	1.04,3.22	0.037
	G3 vs G2-G1	0.82	0.40,1.71	0.603	0.85	0.41,1.77	0.668
OS	SIB	1.15	0.61,2.17	0.674	1.71	0.86,3.40	0.127	1.51	0.77,2.98	0.235
	Sex (M vs F)	2.64	1.38,5.07	0.003	2.77	1.43,5.37	0.003
	Age	1.03	1.00,1.06	0.043	1.03	1.00,1.06	0.031
	Stage III vs I-II	2.27	1.17,4.38	0.015	2.64	1.30,5.34	0.007
	G3 vs G2-G1	1.42	0.66,3.06	0.376	1.48	0.68,3.23	0.326
CIC	SIB	0.71	0.34,1.47	0.352	0.87	0.41,1.85	0.713	0.85	0.39,1.83	0.675
	Sex (M vs F)	0.93	0.39,2.18	0.863	0.83	0.34,2.05	0.690
	Age	1.00	0.98,1.03	0.765	1.00	0.98,1.02	0.878
	Stage III vs I-II	2.09	0.99,4.38	0.052	2.13	0.97,4.70	0.061
	G3 vs G2-G1	0.44	0.13,1.48	0.184	0.43	0.13,1.45	0.173

Legend HR hazard ratio CI confidence interval, M vs F male vs female, UFS colostomy-free survival, OS Overall Survival, CIC Cumulative Incidence of colostomy