Table 4.
Clinico-pathological features of prostate cancer patients treated by radical prostatectomy
| TMA series | Test | Validation | |||
|---|---|---|---|---|---|
| Number of patients | 250 | 1262 | |||
| Mean age at diagnosis | 61 | 61 | |||
| Median follow-up (months) | 113 | 120 | |||
| N | % | N | % | ||
| Gleason score at RP | ≤3 + 3 | 64 | 25.6 | 392 | 31.1 |
| 3 + 4 | 104 | 41.6 | 499 | 39.5 | |
| 4 + 3 | 42 | 16.8 | 188 | 14.9 | |
| ≥4 + 4 | 36 | 14.4 | 175 | 13.9 | |
| NA | 4 | 1.6 | 8 | 0.6 | |
| pTNM | 2 | 171 | 68.4 | 788 | 62.4 |
| 3 | 77 | 30.8 | 453 | 35.9 | |
| 4 | 2 | 0.8 | 21 | 1.7 | |
| Margin status | Negative | 156 | 62.4 | 837 | 66.3 |
| Positive | 91 | 36.4 | 418 | 33.1 | |
| NA | 3 | 1.2 | 7 | 0.6 | |
| Biochemical relapse | No | 173 | 69.2 | 828 | 65.6 |
| Yes | 77 | 30.8 | 434 | 34.4 | |
| Type of biochemical relapse | Rising PSA | 54 | 21.6 | 264 | 20.9 |
| Failed RP | 16 | 6.4 | 85 | 6.7 | |
| Treatment | 7 | 2.8 | 85 | 6.7 | |
| Bone metastasis | No | 239 | 95.6 | 1208 | 95.7 |
| Yes | 11 | 4.4 | 54 | 4.3 | |
| Castrate resistant | No | 237 | 94.8 | 1201 | 95.2 |
| Yes | 13 | 5.2 | 61 | 4.8 | |
| Mortality | PC specific | 4 | 1.6 | 36 | 2.9 |
| Other cause(s) | 17 | 6.8 | 119 | 9.4 | |
| Overall | 21 | 8.4 | 155 | 12.3 | |
TMA tissue microarray, RP radical prostatectomy, pTNM pathological staging, NA not available, Rising PSA serum level of prostate-specific antigen (PSA) of 0.2 ng/mL and rising, Failed RP PSA level after surgery > 0.2 ng/mL, PC prostate cancer