Table 1.
Clinical and epidemiological characteristics of individuals in the study
| Patient | Gender | Age (years) | Year of HIV diagnosis | Years of HIV suppression | Exposure category | Median CD4+ T cells (cells/mm3) | Median CD8+ T cells (cells/mm3) | Viral load frequency (%) | ||
|---|---|---|---|---|---|---|---|---|---|---|
| (IQR) | (IQR) | < 80a | 81–400a | 401–5000a | ||||||
| EC02 | Female | 52 | 1997 | 15 | HET | 1229 (1088–1443) |
1539 (1406–1741) |
100 | ||
| EC17 | Female | 65 | 2000 | 15 | NI | 1771 (1505–2134) |
836 (693–994) |
90 | 10 | |
| EC52 | Female | 43 | 1997 | 18 | HET | 1263 (1056–1420) |
485 (423–540) |
100 | ||
| EC11 | Female | 48 | 1995 | 20 | HET | 1078 (987–1218) |
965 (806–1168) |
92 | 8 | |
| EC18 | Female | 82 | 2001 | 9 | HET | 809 (675–940) |
666 (594–761) |
87 | 13 | |
| EC42 | Female | 61 | 1993 | 22 | HET | 974.5 (871–1133) |
734 (515–933) |
74 | 26 | |
| VC05 | Male | 51 | 1991 | 24 | NI | 1278 (1114–1461) |
857 (645–1009) |
16 | 47 | 17 |
| VC06 | Male | 37 | 2000 | 11 | MSM | 1093 (929–1222) |
1112 (870–1224) |
42 | 50 | 8 |
| VC14 | Female | 45 | 1999 | 16 | HET | 701.5 (652–767) |
657 (585–749) |
55 | 36 | 9 |
| VC15 | Female | 41 | 2001 | 14 | HET | 703 (677–826) |
894 (755–1002) |
100 | ||
| VC16 | Male | 48 | 1998 | 17 | MSM | 563 (528–637) |
837 (719–958) |
21 | 37 | 32 |
| Patient | Genotype HLA-B | Genotype CCR5 | Early visit date | Later visit date | Difference VE × VL (months) |
|---|---|---|---|---|---|
| EC02 | B*48, B*52 | WT/WT | NOV/08 | AUG/12 | 45 |
| EC17 | B*07, B*40 | WT/WT | SEP/09 | OCT/13 | 49 |
| EC52 | B*45, B*57 | WT/WT | FEB/09 | AUG/13 | 54 |
| EC11 | B*49, B*81 | WT/∆32 | DEC/09 | APR/12 | 28 |
| EC18 | B*07, B*52 | WT/WT | OCT/09 | SEP/10 | 11 |
| EC42 | B*15, B*51 | WT/WT | DEC/09 | NOV/14 | 59 |
| VC05 | B*15, B*52 | WT/WT | FEB/09 | JUN/13 | 52 |
| VC06 | B*15, B*48 | WT/∆32 | JAN/09 | MAY/11 | 28 |
| VC14 | B*42, B*44 | WT/WT | APR/09 | NOV/14 | 67 |
| VC15 | B*56, B*57 | WT/WT | AUG/09 | FEB/13 | 42 |
| VC16 | B*14, B*57 | WT/WT | SEP/09 | SEP/14 | 60 |
aCopies/ml
HET heterosexual, NI non-Informed, MSM men who have sex with men, IQR interquartile range, WT wild-type, HLA-B protective alleles are in italic