Table 1.
Characteristics of 87 patients with locoregional recurrent esophageal cancer
| Variables | Number | Percent |
|---|---|---|
| Age (years) | ||
| < 65 | 58 | 66.7 |
| ≥ 65 | 29 | 33.3 |
| KPS | ||
| 70–80 | 32 | 36.8 |
| >80 | 55 | 63.2 |
| Gender | ||
| Male | 65 | 74.7 |
| Female | 22 | 25.3 |
| Smoking | ||
| Yes | 31 | 35.6 |
| No | 56 | 64.4 |
| Alcohol consumption | ||
| Yes | 15 | 17.2 |
| No | 72 | 82.8 |
| Primary tumor location | ||
| Upper thoracic | 34 | 39.1 |
| Middle and lower thoracic | 53 | 60.9 |
| Initial clinical stage | ||
| I + II | 23 | 32.9 |
| III | 47 | 67.1 |
| Initial treatment | ||
| Surgery + adjuvant radio(chemo)therapy | 11 | 12.6 |
| Definitive chemoradiotherapy | 39 | 44.8 |
| Definitive radiotherapy | 37 | 42.6 |
| Pattern of recurrence | ||
| Regional lymph node recurrence only | 14 | 16.1 |
| Local failure | 62 | 71.3 |
| Both | 11 | 12.6 |
| Radiation dose in the initial treatment (Gy) | ||
| ≤ 50 | 12 | 13.8 |
| > 50 | 75 | 86.2 |
| Recurrence-free interval (months) | ||
| ≤ 12 | 38 | 43.7 |
| > 12 | 49 | 56.3 |
| Chemotherapy after recurrence | ||
| Yes | 26 | 29.9 |
| No | 61 | 70.1 |
| Re-RT after recurrence | ||
| Yes | 39 | 44.8 |
| No | 48 | 55.2 |
| Treatment moditily after recurrence | ||
| Re-RT only | 20 | 23.0 |
| CRT only | 7 | 8.0 |
| Re-RT concomitant chemotherapy | 19 | 21.8 |
| Best supportive care | 39 | 43.7 |
| Salvage total esophagectomy | 3 | 3.4 |
Abbreviation: Re-RT Re-irradiation, KPS Karnofsky performance status