Table 2.
Demodex canis mite count reduction in dogs treated three times at a monthly interval with oral afoxolaner
| Day 0 | Day 28 | Day 56 | Day 84 | |
|---|---|---|---|---|
| Total number of dogs (n) | 50 | 50 | 49 | 48 |
| Mean mite count (n) | 183 | 22.8 | 6.4 | 3.5 |
| Count range (n) | 13–2349 | 0–191 | 0–65 | 0–53 |
| Reduction (%) | na | 87.6 | 96.5 | 98.1 |
| Mite-free dogs (%)a (no. of mite-free dogs/total no. of dogs) | na | 12 (6/50) | 38.8 (19/49) | 62.5 (30/48) |
| Signed rank (S) | na | -599 | -612 | -588 |
| Degrees of freedom | na | 48 | 48 | 47 |
| P-value | na | <0.0001 | <0.0001 | <0.0001 |
| NexGard-treated animals | ||||
| Number of dogs (n) | 31 | 31 | 30 | 29 |
| Mean mite count (n) | 229.8 | 26.5 | 7.4 | 4.1 |
| Count range (n) | 18–2349 | 0–191 | 0–65 | 0–53 |
| Reduction (%) | na | 88.5 | 96.8 | 98.2 |
| Signed rank (S) | na | -224 | -232.5 | -217.5 |
| Degrees of freedom | 29 | 29 | 28 | |
| P-value | na | <0.0001 | <0.0001 | <0.0001 |
| NexGard Spectra-treated animals | ||||
| Number of dogs (n) | 19 | 19 | 19 | 19 |
| Mean mite count (n) | 106.6 | 16.8 | 4.8 | 2.7 |
| Count range (n) | 13–386 | 0–91 | 0–26 | 0–37 |
| Reduction (%) | na | 84.3 | 95.5 | 97.5 |
| Signed rank (S) | na | -95 | -95 | -95 |
| Degrees of freedom | na | 18 | 18 | 18 |
| P-value | na | <0.0001 | <0.0001 | <0.0001 |
Abbreviation: na not applicable
a Mite-free dogs: absence of mite (live or dead) at count