Table 5.
Individual lesion and extent scores (Day 0 and Day 84) for 31 dogs treated with afoxolaner who didn’t received concomitant medications for the control of skin conditions
| Lesion | Severity | Extent | ||||
|---|---|---|---|---|---|---|
| Day 0 | Day 84 | Day 0 | Day 84 | |||
| Alopecia | Absent (%) | 0 | 78.1 | Absent (%) | 0 | 78.1 |
| Mild (%) | 18.2 | 18.8 | Limited (%)a | 54.5 | 21.9 | |
| Moderate (%) | 33.3 | 3.1 | Marked (%)b | 39.4 | 0 | |
| Severe (%) | 48.5 | 0 | Generalised (%)c | 6.1 | 0 | |
| CMH row mean scores differ | F(1, 63) = 46.7; P <0.0001 | CMH row mean scores differ | F(1, 63) = 42.3; P <0.0001 | |||
| Erythema | Absent (%) | 12.1 | 87.5 | Absent (%) | 12.1 | 87.5 |
| Mild (%) | 18.2 | 9.4 | Limited (%)a | 51.5 | 12.5 | |
| Moderate (%) | 24.2 | 3.1 | Marked (%)b | 27.3 | 0 | |
| Severe (%) | 45.5 | 0 | Generalised (%)c | 9.1 | 0 | |
| CMH row mean scores differ | F(1, 63) = 38.1; P <0.0001 | CMH row mean scores differ | F(1, 63) = 36.3; P <0.0001 | |||
| Papules | Absent (%) | 53.1 | 93.8 | Absent (%) | 53.1 | 93.8 |
| Mild (%) | 12.5 | 3.1 | Limited (%)a | 25.0 | 6.3 | |
| Moderate (%) | 12.5 | 3.1 | Marked (%)b | 21.9 | 0 | |
| Severe (%) | 21.9 | 0 | Generalised (%)c | 0 | 0 | |
| CMH row mean scores differ | F(1, 62) = 13.8; P = 0.0002 | CMH row mean scores differ | F(1, 62) = 13.9; P = 0.0001 | |||
| Pustules | Absent (%) | 56.3 | 96.9 | Absent (%) | 56.3 | 96.9 |
| Mild (%) | 12.5 | 0 | Limited (%)a | 21.9 | 3.1 | |
| Moderate (%) | 18.8 | 3.1 | Marked (%)b | 21.9 | 0 | |
| Severe (%) | 12.5 | 0 | Generalised (%)c | 0 | 0 | |
| CMH row mean scores differ | F(1, 62) = 14.2; P = 0.0002 | CMH row mean scores differ | F(1, 62) = 14.7; P = 0.0001 | |||
| Scaling crusts | Absent (%) | 39.4 | 96.9 | Absent (%) | 21.2 | 93.8 |
| Mild (%) | 15.2 | 3.1 | Limited (%)a | 51.5 | 6.3 | |
| Moderate (%) | 24.2 | 0 | Marked (%)b | 21.2 | 0 | |
| Severe (%) | 0 | 0 | Generalised (%)c | 6.1 | 0 | |
| CMH row mean scores differ | F(1, 63) = 32.1; P <0.0001 | CMH row mean scores differ | F(1, 63) = 33.5; P <0.0001 | |||
Note: 17 animals were excluded from the analyses because of concomitant medications for the control of skin conditions
aSeen on 1/3 of the (head + body) surface
bSeen on 2/3 of the (head + body) surface
cSeen all over the head + body