Table 1. Genotype and allele frequency of lipoprotein lipase gene; -93 T<G promoter (rs1800590) polymorphism in study subjects according to body mass index (BMI) and insulin resistance.
| Study subjects classified based on BMI | p-value* | |||
|---|---|---|---|---|
| Obese subjects n (%) |
Non-obese subjects n (%) |
OR (95% CI) | ||
| Genotype | ||||
| TT | 257 (83.2) | 310 (93.1) | Reference | Reference |
| TG | 47 (15.2) | 22 (6.6) | 2.58 (1.51–4.39) | < 0.001 |
| GG | 5 (1.6) | 1 (0.3) | 6.03 (0.70–51.95) | 0.102 |
| TG+GG | 52 (16.8) | 23 (6.9) | 2.73 (1.63–4.58) | < 0.001 |
| Allele | ||||
| T | 561 (90. 8) | 642 (96.4) | Reference | Reference |
| G | 57 (9.2) | 24 (3.6) | 2.13 (1.55–3.97) | < 0.001 |
| Study subjects classified based on insulin resistance status (HOMA) | ||||
|---|---|---|---|---|
| Insulin resistant subjects n (%) | Non-insulin resistant subjects n (%) | OR (95% CI) | p-value** | |
| Genotype | ||||
| TT | 208 (88.5) | 359 (88.2) | Reference | Reference |
| TG | 24 (10.2) | 45 (11.1) | 0.92 (0.55–1.56) | 0.757 |
| GG | 3 (1.3) | 3 (0.7) | 1.73 (0.35–8.63) | 0.506 |
| TG+GG | 27 (11.5) | 48 (11.8) | 0.97 (0.59–1.60) | 0.908 |
| Allele | ||||
| T | 440 (93.6) | 763 (93.7) | Reference | Reference |
| G | 30 (6.4) | 51 (6.3) | 0.98 (0.66–1.48) | 0.834 |
Total number of obese (n = 309) and non-obese subjects (n = 333) (for genotype); total number of chromosomes in obese (n = 618) and non-obese subjects (n = 666) (for alleles); total number of insulin resistant (n = 235) and non-insulin resistant subjects (n = 407) (for genotype); total number of chromosomes in insulin resistant (n = 470) and non-insulin resistant subjects (n = 814) (for alleles). *adjusted for age and sex.
**adjusted for age, sex, and BMI.
HOMA: homeostasis model assessment; OR: odds ratio; CI: confidence interval.