Table 4. Genotype and allele frequency of the lipoprotein lipase gene; -53 G<C promoter polymorphism in study subjects according to body mass index (BMI) and insulin resistance.
| Study subjects classified based on BMI | p-value* | |||
|---|---|---|---|---|
| Obese subjects n (%) |
Non-obese subjects n (%) |
OR (95%CI) | ||
| Genotype | ||||
| GG | 283 (91.6) | 304 (91.3) | Reference | Reference |
| GC | 14 (4.5) | 26 (7.8) | 0.57 (0.29–1.12) | 0.105 |
| CC | 12 (3.9) | 3 (0.9) | 2.93 (0.92–9.32) | 0.068 |
| GC + CC | 26 (8.4) | 29 (8.7) | 0.89 (0.51–1.55) | 0.678 |
| Allele | ||||
| G | 580 (93.9) | 634 (95.2) | Reference | Reference |
| C | 38 (6.1) | 32 (4.8) | 0.78 (0.58–1.43) | 0.823 |
| Study subjects classified based on insulin resistance status (HOMA) | ||||
|---|---|---|---|---|
| Insulin resistant subjects n (%) | Non-insulin resistant subjects n (%) | OR (95% CI) | p-value** | |
| Genotype | ||||
| GG | 190 (80.9) | 397 (97.5) | Reference | Reference |
| GC | 37 (15.7) | 3 (0.7) | 40.01 (9.55–167.60) | < 0.001 |
| CC | 8 (3.4) | 7 (1.7) | 2.41 (0.860–6.74) | 0.094 |
| GC + CC | 45 (19.1) | 10 (2.4) | 10.76 (5.16–11.45) | < 0.001 |
| Allele | ||||
| G | 417 (88.7) | 797 (97.9) | Reference | Reference |
| C | 53 (11.3) | 17 (2.1) | 2.78 (1.56–3.55) | < 0.001 |
Total number of obese (n = 309) and non-obese subjects (n = 333) (for genotype); total number of chromosomes in obese (618) and non-obese subjects (n = 666) (for alleles); total number of insulin resistant (n = 235) and non-insulin resistant subjects (n = 407) (for genotype); total number of chromosomes in insulin resistant (n = 470) and non-insulin resistant subjects (n = 814) (for alleles). *adjusted for age and sex.
**adjusted for age, sex, and BMI.
HOMA: homeostasis model assessment; OR: odds ratio; CI: confidence interval.