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. 2018 Sep 10;20:207. doi: 10.1186/s13075-018-1701-1

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© The Author(s). 2018

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 1 — Gross macrographs and body and uterus weight changes of mice after ovariectomy. a There is a remarkable accumulation of fat in the abdominal cavity (black open arrow) and the body weight increase significantly over time in ovariectomized (OVX) mice. b The uterus is visibly atrophied in the OVX group and is significant lighter in weight compared with the control (ct) group. Data are shown as mean ± SD; n = 15 per group. ^a–kp < 0.05 vs control group at 2–12 weeks for body weight; *p < 0.05 vs control group for uterus weight